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Lixisenatide

Name
Lixisenatide
Molecular structural formula
Purity
≥98%
CAS Number
320367-13-3
Formula
C215H347N61O65S
MW
4858.5
Target
Amylin Receptor
Sequence
His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-lle-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Ser-Lys-Lys-Lys-Lys-Lys-Lys
Sequence Shortening
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPSKKKKKK
InChIKey
XVVOERDUTLJJHN-IAEQDCLQSA-N
References
[1].Liu J, Li L, Deng K, Xu C, Busse JW, Vandvik PO, et al. (June 2017). [2]. Cai HY, Yang JT, Wang ZJ, Zhang J, Yang W, Wu MN, Qi JS (January 2018). "Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease". Biochemical and Biophysical Research Communications. 495 (1): 1034–1040.
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Lixisenatide belongs to the category of GLP-1 receptor agonists, which effectively controls blood sugar levels by promoting insulin secretion, inhibiting glucagon release, and delaying gastric emptying. For patients who are not effective in diet control and exercise therapy, lixisenatide can be used as a supplement to insulin therapy and has shown good cardiovascular safety.