Filters
Catalog peptides
Synthesis of unnatural amino acids and other blocks

Jagged-1 (188-204)

Name
Jagged-1 (188-204)
Molecular structural formula
Purity
≥98%
CAS Number
219127-21-6
Formula
C93H127N25O26S3
MW
2107.35
Target
Notch
Sequence
Cys-Asp-Asp-Tyr-Tyr-Tyr-Gly-Phe-Gly-Cys-Asn-Lys-Phe-Cys-Arg-Pro-Arg
Sequence Shortening
CDDYYYGFGCNKFCRPR
References
[1]. Jundt F, et al. Jagged1-induced Notch signaling drives proliferation of multiple myeloma cells. Blood. 2004 May 1;103(9):3511-5. [2]. Weijzen S, et al. The Notch ligand Jagged-1 is able to induce maturation of monocyte-derived human dendriticcells. J Immunol. 2002 Oct 15;169(8):4273-8. [3]. Nickoloff BJ, et al. Jagged-1 mediated activation of notch signaling induces complete maturation of human keratinocytes through NF-kappaB and PPARgamma. Cell Death Differ. 2002 Aug;9(8):842-55.
* All products on our website are for scientific research and cannot be used in human body
Product details
Data download

Jagged-1 (188-204) is a functional fragment of the JAG-1 protein. As an activator of the Notch signaling pathway, it has a significant effect on cell fate, proliferation, differentiation, and apoptosis, and promotes the maturation of monocyte-derived dendritic cells. In addition, this fragment is also involved in the process of pulmonary fibrosis and affects the transformation of cell phenotypes. It is used to study the Notch signaling pathway in the field of scientific research.