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Icatibant acetate

Name
Icatibant acetate
Molecular structural formula
Purity
≥98%
CAS Number
138614-30-9
Formula
C61H93N19O15S
MW
1364.57
Target
Bradykinin Receptor
Sequence
D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-Oic-Arg-OH
Sequence Shortening
rRP-{Hyp}-G-2Thi-S-{D-Tic}-Oic-R
InChIKey
HKMZRZUEADSZDQ-DZJWSCHMSA-N
Solubility in DMSO
100 mg/mL
References
[1]. Hock FJ, et al. Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br J Pharmacol. 1991 Mar;102(3):769-73. [2]. Y Arai, et al. Effect of Icatibant, a Bradykinin B2 Receptor Antagonist, on the Development of Experimental Ulcerative Colitis in Mice. Dig Dis Sci. 1999 Apr;44(4):845-51. [3]. Marie-Thérèse Bawolak, et al The Bradykinin B2 Receptor Antagonist Icatibant (Hoe 140) Blocks Aminopeptidase N at Micromolar Concentrations: Off-Target Alterations of Signaling Mediated by the Bradykinin B1 and Angiotensin Receptors. Eur J Pharmacol. 2006 Dec 3;551(1-3):108-11.
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Product details
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Icatibant acetate is a potent and selective bradykinin type 2 (B2) receptor antagonist that selectively blocks the effects of bradykinin through a competitive mechanism.