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Home / Peptide products / Catalog peptides / H (67 species) / Histatin /
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Histatin 5

Name
Histatin 5
Molecular structural formula
Purity
≥95%
CAS Number
115966-68-2
Formula
C133H195N51O33
MW
3036.36
Target
MMP
Sequence
Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr
Sequence Shortening
DSHAKRHHGYKRKFHEKHHSHRGYRSNY
InChIKey
KSXBMTJGDUPBBN-VPKNIDFUSA-N
References
[1]. Gusman H, et al. Salivary histatin 5 is an inhibitor of both host and bacterial enzymes implicated in periodontaldisease. Infect Immun. 2001 Mar;69(3):1402-8. [2]. Helmerhorst EJ, et al. The human salivary peptide histatin 5 exerts its antifungal activity through the formation ofreactive oxygen species. Proc Natl Acad Sci U S A. 2001 Dec 4;98(25):14637-42.
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Product details
Data download

Histatin 5 inhibits the activity of the host matrix metalloproteinases MMP-2 and MMP-9 with IC50s of 0.57 and 0.25 μM, respectively.