Hemokinin 1, human is a selective tachykinin neurokinin 1 (NK1) receptor full agonist. Hemokinin 1, human is a full agonist at NK2 and NK3 receptor. Hemokinin 1, human can produces an opioid-independent analgesia.
Hemokinin 1 (human) is an endogenous substance P homolog and acts as a selective agonist at the tachykinin NK1 receptor (IC50 = 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors, respectively). It induces proliferation of B-cells in vitro and exhibits antihypertensive activity in vivo.