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α-Helical CRF (9-41)

Name
α-Helical CRF (9-41)
Molecular structural formula
Purity
≥95%
Price

1mg: $66.50

5mg: $196.00

10mg: $329.00
CAS Number
90880-23-2
Formula
C166H274N46O53S2
MW
3826.44
Target
CRFR
Sequence
Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2
Sequence Shortening
DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2
InChIKey
PNGVJHODDQMQKT-GVKLFNHCSA-N
Solubility in water
50 mg/mL
References
[1]. Sonia Tucci, et al. Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety. Psychopharmacology (Berl). 2003 May;167(3):251-6. [2]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.
* All products on our website are for scientific research and cannot be used in human body
Product details
Data download

α-Helical CRF(9-41) is a competitive CRF2 receptor antagonist with KB of ~100 nM. α-Helical CRF(9-41) is also a partial agonist of CRF1 receptor with an EC50 of 140 nM.