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Home / Peptide products / Catalog peptides / H (67 species) / HIV /
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HIV-1 tat Protein (49-57)

Name
HIV-1 tat Protein (49-57)
Molecular structural formula
Purity
≥95%
CAS Number
123251-89-8
Formula
C53H106N30O11
MW
1339.63
Target
HIV
Sequence
Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg
Sequence Shortening
RKKRRQRRR
InChIKey
KXLZCNROAUAFRT-IZROAPMXSA-N
References
[1].Bianchi E, Finotto M, Ingallinella P, Hrin R, Carella AV, Hou XS, Schleif WA, Miller MD, Geleziunas R, Pessi A (2005). Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection. PNAS., 102(36):12903-12908 [2].de Rosny E, Vassell R, Jiang S, Kunert R, Weiss CD (2004). Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes. J. Virol., 78(5):2627-2631. [3]. Klostermeier D, Bayer P, Kraft M, Frank RW, Rösch P (1997). Spectroscopic investigations of HIV-1 trans-activator and related peptides in aqueous solutions. Biophysical Chemistry, 63(2):87-96. [4].Ho DD, Kaplan JC, Rackauskas IE, Gurney ME (1988). Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization. Science, 239(4843):1021-1023.
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RKKRRQRRR, a nine amino acid motif within the HIV-1 tat protein transduction domain (PTD), suffices for the transduction of heterologous proteins through the plasma membrane.