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HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22)

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Name HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22)	Molecular structural formula
Purity ≥95%
CAS Number 114991-28-5
Formula C73H126N26O18
MW 1655.98
Target HIV
Sequence Arg-Ile-Gln-Arg-Gly-Pro-Gly-Arg-Ala-Phe-Val-Thr-Ile-Gly-Lys
Sequence Shortening RIQRGPGRAFVTIGK
InChIKey SMHASQROABALLM-ROQHZCFESA-N
References [1].Bianchi E, Finotto M, Ingallinella P, Hrin R, Carella AV, Hou XS, Schleif WA, Miller MD, Geleziunas R, Pessi A (2005). Covalent stabilization of coiled coils of the HIV gp41 N region yields extremely potent and broad inhibitors of viral infection. PNAS., 102(36):12903-12908 [2].de Rosny E, Vassell R, Jiang S, Kunert R, Weiss CD (2004). Binding of the 2F5 monoclonal antibody to native and fusion-intermediate forms of human immunodeficiency virus type 1 gp41: implications for fusion-inducing conformational changes. J. Virol., 78(5):2627-2631. [3]. Klostermeier D, Bayer P, Kraft M, Frank RW, Rösch P (1997). Spectroscopic investigations of HIV-1 trans-activator and related peptides in aqueous solutions. Biophysical Chemistry, 63(2):87-96. [4].Ho DD, Kaplan JC, Rackauskas IE, Gurney ME (1988). Second conserved domain of gp120 is important for HIV infectivity and antibody neutralization. Science, 239(4843):1021-1023.

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HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22), derived from the V3 loop of HIV-1 IIIB gp120 efficiently blocked HIV-1 IIIB infection of several T-cell lines and of normal human T cells. RIQRGPGRAFVTIGK also blocked syncytium formation in human cells. Moreover, HIV-1 env Protein gp120 (278-292) (strains BH10, BH8, HXB2, HXB3, PV22) was capable of inducing HIV-1 specific cytotoxic T lymphocyte responses that could effectively kill virus-infected cells and could thus find several therapeutic applications.