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GAP 26

Name
GAP 26
Molecular structural formula
Purity
≥95%
CAS Number
197250-15-0
Formula
C70H107N19O19S
MW
1550.78
Target
Gap Junction Protein
Sequence
Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg
Sequence Shortening
VCYDKSFPISHVR
InChIKey
FDPIMWZHGJNESB-VCSXYVMHSA-N
References
[1]. Katleen Braet, et al. Photoliberating inositol-1,4,5-trisphosphate triggers ATP release that is blocked by the connexin mimetic peptide gap 26. Cell Calcium. 2003 Jan;33(1):37-48. [2]. Chaytor AT, et al. Peptides homologous to extracellular loop motifs of connexin 43 reversibly abolish rhythmic contractile activity in rabbit arteries. J Physiol. 1997 Aug 15;503 ( Pt 1):99-110.
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Gap 26 is a connexin mimetic peptide, composed of residue numbers 63-75 of the first extracellular loop of connexin 43 (gap junction blocker), containing the SHVR amino acid motif