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Fibronectin Adhesion-Promoting Peptide

Name
Fibronectin Adhesion-Promoting Peptide
Molecular structural formula
Purity
95%
CAS Number
125720-21-0
Formula
C47H74N16O10
MW
1023.19
Target
others
Sequence
Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile
Sequence Shortening
WQPPRARI
InChIKey
OVXIMRGEBNSORH-PJRZOMOUSA-N
Solubility in water
2 mg/mL
References
[1]. Hoesli CA, et al. A fluorophore-tagged RGD peptide to control endothelial cell adhesion to micropatterned surfaces. Biomaterials. 2014 Jan;35(3):879-90. [2]. Chollet C, et al. Impact of peptide micropatterning on endothelial cell actin remodeling for cell alignment under shear stress. Macromol Biosci. 2012 Dec;12(12):1648-59. [3]. Lei J, Murphy WL, et al. Combination of Heparin Binding Peptide and Heparin Cell Surface Coatings for Mesenchymal Stem Cell Spheroid Assembly. Bioconjug Chem. 2018 Apr 18;29(4):878-884.
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Fibronectin Adhesion-promoting Peptide (Heparin Binding Peptide) is one of the heparin-binding amino acid sequences found in the carboxy-terminal heparin-binding domain of fibronectin. It promotes assembly of mesenchymal stem cell (MSC) spheroids into larger aggregates. Fibronectin Adhesion-promoting Peptide directly promotes the adhesion, spreading, and migration of endothelial cells by reacting with heparin binding domains of cells.