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Synthesis of unnatural amino acids and other blocks

Fequesetide

Name
Fequesetide
Molecular structural formula
Purity
95%
CAS Number
476014-70-7
Formula
C36H66N10O13
MW
846.97
Target
Arp2/3 Complex
Sequence
Leu-Lys-Lys-Thr-Glu-Thr-Gln
Sequence Shortening
LKKTETQ
InChIKey
LVLWJWXFRFTMLK-JMWNXRNDSA-N
Solubility in water
≥ 100 mg/mL
References
[1].Emmie N M Ho, et al. Doping control analysis of TB-500, a synthetic version of an active region of thymosin β₄, in equine urine and plasma by liquid chromatography-mass spectrometry. J Chromatogr A. 2012 Nov 23;1265:57-69..
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This peptide is a common actin-binding domain of thymosin beta4 and beta10. It significantly enhances skin wound healing in-vitro and in-vivo, that may be mediated by purinergic receptors. This actin-binding domain is also active in endothelial cell migration and vessel sprouting.