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Enfuvirtide

Name
Enfuvirtide
Molecular structural formula
Purity
≥98%
CAS Number
159519-65-0
Formula
C204H301N51O64
MW
4491.94
Target
HIV
Sequence
Ac-Tyr-Thr-Ser-Leu-Ile-His-Ser-Leu-Ile-Glu-Glu-Ser-Gln-Asn-Gln-Gln-Glu-Lys-Asn-Glu-Gln-Glu-Leu-Leu-Glu-Leu-Asp-Lys-Trp-Ala-Ser-Leu-Trp-Asn-Trp-Phe-NH2(trifluoroacetate salt)
Sequence Shortening
Ac-YTSLIHSLIEESQNQQEKNEQELLELDKWASLWNWF-NH2(trifluoroacetate salt)
Solubility in DMSO
20 mg/mL
Solubility in water
< 0.1 mg/mL
References
[1]. Figueira TN, et al. Quantitative analysis of molecular partition towards lipid membranes using surface plasmon resonance. Sci Rep. 2017 Mar 30;7:45647. [2]. Cao P, et al. The improved efficacy of Sifuvirtide compared with Enfuvirtide might be related to its selectivity for the rigid biomembrane, as determined through surface plasmon resonance. PLoS One. 2017 Feb 16;12(2):e0171567. [3]. Wang X, et al. IFN-λ Inhibits Drug-Resistant HIV Infection of Macrophages. Front Immunol. 2017 Mar 6;8:210.
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Product details
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This product is a synthetic peptide HIV fusion inhibitor, which can bind to the viral envelope glycoprotein and prevent the conformational changes necessary for the fusion of the virus and the cell membrane, thereby inhibiting the replication of HIV-1. Enfuvirtide is derived from an amino acid sequence in the HR2 domain of gp41, which prevents the interaction between HR1 and HR2 and the change of gp41 configuration by mimicking the activity of the HR2 domain and competing for binding to the HR1 domain of gp41, thereby preventing the fusion of the virus with the host cell.