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Synthesis of unnatural amino acids and other blocks

Elcatonin

Name
Elcatonin
Molecular structural formula
Purity
≥98%
CAS Number
60731-46-6
Formula
C148H244N42O47
MW
3363.77
Sequence
Ser-Asn-Leu-Ser-Thr-Asu-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2 (Ser1-Asu Lacton)
Sequence Shortening
SNLST(Asu)VLGKLSQELHKLQTYPRTDVGAGTP-NH2(Ser1-Asu Lacton)
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Lecatonin, also known as calcinin, is a new type of calcitonin synthesized artificially; It has the effect of lowering blood calcium and blood phosphorus, and also inhibits the bone resorption promotion effect of prostaglandin E1, 1,25-(OH)2 vitamin D2 and osteoclast activating factor, and can also inhibit the secretion of gastric juice and gastric acid, promote the excretion of Na+ and K+ from urine, increase urine output, and increase the ratio of Na+/K+; Clinically, it is often used for degenerative osteitis (Paget's disease), osteoporosis, hypercalcemia, and painful bone disease; It is also used for renal osteodystrophy and bone metastasis of malignant tumors.