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Dynorphin A (1-10), porcine

Name
Dynorphin A (1-10), porcine
Molecular structural formula
Purity
≥95%
Price

1mg: $21.00

5mg: $59.50

10mg: $98.00

CAS Number
79994-24-4
Formula
C57H91N19O12
MW
1234.48
Target
NMDA Receptor κ Opioid Receptor/KOR
Sequence
Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro
Sequence Shortening
YGGFLRRIRP
References
[1]. Paterlini G, et al. Molecular simulation of dynorphin A-(1-10) binding to extracellular loop 2 of the kappa-opioidreceptor. A model for receptor activation. J Med Chem. 1997 Sep 26;40(20):3254-62. [2]. Chen L, et al. Dynorphin block of N-methyl-D-aspartate channels increases with the peptide length. J Pharmacol Exp Ther. 1998 Mar;284(3):826-31.
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Dynorphin A (1-10) an endogenous opioid neuropeptide, binds to extracellular loop 2 of the κ-opioid receptor. Dynorphin A (1-10) also blocks NMDA-activated current with an IC50 of 42.0 μM.