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Dermorphin

Name
Dermorphin
Molecular structural formula
Purity
≥95%
CAS Number
77614-16-5
Formula
C40H50N8O10
MW
802.88
Target
Opioid Receptor
Sequence
Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2
Sequence Shortening
Y-{D-Ala}-FGYPS-NH2
InChIKey
FHZPGIUBXYVUOY-VWGYHWLBSA-N
Solubility in water
120 mg/mL
References
[1]. Tiwari V, et al. Activation of Peripheral μ-opioid Receptors by Dermorphin [D-Arg2, Lys4] (1-4) Amide Leads to Modality-preferred Inhibition of Neuropathic Pain. Anesthesiology. 2016 Mar;124(3):706-20. [2]. Bird MF, et al. Characterisation of the Novel Mixed Mu-NOP Peptide Ligand Dermorphin-N/OFQ (DeNo). PLoS One. 2016 Jun 7;11(6):e0156897.
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Dermorphin is a natural heptapeptide μ-opioid receptor (MOR) agonist found in amphibian skin. Inhibition of neuropathic pain.