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Cyclosomatostatin

Name
Cyclosomatostatin
Molecular structural formula
Purity
95%
CAS Number
84211-54-1
Formula
C44H57N7O6
MW
779.98
Target
Somatostatin Receptor
Sequence
Cyclo(-7-aminoheptanoyl-Phe-D-Trp-Lys-Thr(Bzl))
Sequence Shortening
Cyclo(-7-aminoheptanoyl-DwKT(Bzl))
InChIKey
YHVHQZYJGWGAKN-ZUWUZHNASA-N
Solubility in water
10 mg/mL
References
[1]. Shirin R Modarai, et al. Somatostatin signaling via SSTR1 contributes to the quiescence of colon cancer stem cells. BMC Cancer. 2016 Dec 7;16(1):941.
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Cyclosomatostatin is a potent somatostatin (SST) receptor antagonist. Cyclosomatostatin can inhibit somatostatin receptor type 1 (SSTR1) signaling and decreases cell proliferation, ALDH+ cell population size and sphere-formation in colorectal cancer (CRC) cells.