Name
Cyclin-A1 -HLA A2(Peptide Sequence: SLMEPPAVLLL)
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Molecular structural formula
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Peptide Sequence
SLMEPPAVLLL
SLMEPPAVLLL
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Lymphocyte Stimulation
peptide
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NCBI Gene SummaryNCBI
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin encoded by this gene was shown to be expressed in testis and brain, as well as in several leukemic cell lines, and is thought to primarily function in the control of the germline meiotic cell cycle. This cyclin binds both CDK2 and CDC2 kinases, which give two distinct kinase activities, one appearing in S phase, the other in G2, and thus regulate separate functions in cell cycle.
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GeneCards Summary
CCNA1 (Cyclin A1) is a Protein Coding gene. Diseases associated with CCNA1 include Myeloid Leukemia and Testicular Cancer. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Homology Directed Repair. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA2.
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UniProtKB SwissProt Summary
May be involved in the control of the cell cycle at the G1/S (start) and G2/M (mitosis) transitions. May primarily function in the control of the germline meiotic cell cycle and additionally in the control of mitotic cell cycle in some somatic cells. (CCNA1_HUMAN,P78396)
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References
[1].Teck AT, Urban S, Quass P, Nelde A, Schuster H, Letsch A, Busse A, Walz JS, Keilholz U, Ochsenreither S. Cancer testis antigen Cyclin A1 harbors several HLA-A*02:01-restricted T cell epitopes, which are presented and recognized in vivo. Cancer Immunol Immunother. 2020 Jul 69(7):1217-1227. (PMID: 32157447).
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