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Synthesis of unnatural amino acids and other blocks

Chorionic Gonadotropin-β(109-145) (human)

Name
Chorionic Gonadotropin-β(109-145) (human)
Molecular structural formula
CAS Number
72979-70-5
Formula
C50H75N16O21S
MW
1268.31
Sequence Shortening
TCDDPRFQDSSSSKAPPPSLPSPSRLPGPSDTPILPQ
Sequence
Thr-Cys-Asp-Asp-Pro-Arg-Phe-Gln-Asp-Ser-Ser-Ser-Ser-Lys-Ala-Pro-Pro-Pro-Ser-Leu-Pro-Ser-Pro-Ser-Arg-Leu-Pro-Gly-Pro-Ser-Asp-Thr-Pro-Ile-Leu-Pro-Gln
Purity
≥95%
References
1.de Medeiros SF, Norman RJ (2009). Human choriogonadotrophin protein core and sugar branches heterogeneity: basic and clinical insights. Hum Reprod Update, 15(1):69-95. 2.Ascheim S and Zondek B (1927). Das Hormon des Hypophysenvorderlappens: testobjekt zum nachweis des hormons. Klin Wochenschr 6,248–252. 3.Stenman UH, Tiitinen A, Alfthan H, Valmu L (2006) The classification, functions and clinical use of different isoforms of HCG. Hum Reprod Update, 12(6):769-84. 4.Albertini A, Ghielmi S and Belloli S (1982). Structure, immunochemical properties and immunoassay of human chorionic gonadotropin. Intl. J. Clin. & Lab. Res., 12(1), 289-298.
Target
HIV1
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Human chorionic gonadotropin (hCG) is a glycoprotein hormone produced during pregnancy1. It is made by the developing embryo soon after conception1. Its role is to prevent the disintegration of the corpus luteum of the ovary and thereby maintain progesterone production that is critical for a pregnancy in humans1.