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Caspase 3 (Apopain) Inhibitor 1b

Name
Caspase 3 (Apopain) Inhibitor 1b
Molecular structural formula
CAS Number
178603-73-1
Formula
C28H42N6O12S1
MW
686.73
Sequence Shortening
Biotinyl-DEVD-CHO
Sequence
Biotinyl-Asp-Glu-Val-Asp-CHO
InChIKey
NOYOANDLKBWUGA-AUJWPLEISA-N
Purity
95%
References
[1]. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. [2].Probing the caspase-3 active site by fluorescence lifetime measurements
Target
Caspase
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Product details
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This biotinylated apopain inhibitor has successfully been used for the affinity purification - on a streptavidin-agarose column - of caspase-3 (apopain), the enzyme that cleaves the poly(ADP-ribose) polymerase (PARP). Biotinyl-DEVD-CHO showed an inhibitory activity comparable to that of the N-acetylated analog inhibitor (H-2496) (IC₅₀ = 0.2 nM).