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Synthesis of unnatural amino acids and other blocks

Carperitide

Name
Carperitide
Molecular structural formula
Purity
≥98%
CAS Number
89213-87-6
Formula
C127H203N45O39S3
MW
3080.44
Target
NPR-A
Sequence
Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr(Disulfide bridge: Cys7-Cys23)
Sequence Shortening
SLRRSSCFGGRMDRIGAQSGLGCNSFRY(Disulfide bridge: Cys7-Cys23)
InChIKey
NSQLIUXCMFBZME-MPVJKSABSA-N
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Carperitide is a potent natriuretic peptide receptor (NPR)-A agonist with an EC50 value of 10.8 nM. Carperitide is used to treat congestive heart failure.