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Calpain Inhibitor III; Z-Val-Phe-CHO

Name
Calpain Inhibitor III; Z-Val-Phe-CHO
Molecular structural formula
Purity
95%
CAS Number
88191-84-8
Formula
C22H26O4N2
MW
382.45
Target
Proteasome
Sequence
Cbz-Val-Phe-CHO
Sequence Shortening
Z-VF-CHO
InChIKey
NGBKFLTYGSREKK-ANYOKISRSA-N
Solubility in DMSO
30 mg/mL
References
[1]. Calpain inhibitor MDL28170 modulates Abeta formation by inhibiting the formation of intermediate Abeta46 and protecting Abeta from degradation. [2]. Changes in calcium dynamics following the reversal of the sodium-calcium exchanger have a key role in AMPA receptor-mediated neurodegeneration via calpain activation in hippocampal neurons [3]. Podocyte-associated talin1 is critical for glomerular filtration barrier maintenance.
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Application of the calpain inhibitor Z-VF-CHO reduced capsaicin-mediated cell death in cultured dorsal root ganglion neurons. Dong et al. observed that this inhibitor modulated Aβ formation by inhibiting the formation of intermediate Aβ 1-46 and protecting Aβ from degradation.