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Synthesis of unnatural amino acids and other blocks

CREBtide

Name
CREBtide
Molecular structural formula
Purity
95%
CAS Number
149155-45-3
Formula
C73H129N29O19
MW
1716.99
Target
PKA
Sequence
Lys-Arg-Arg-Glu-Ile-Leu-Ser-Arg-Arg-Pro-Ser-Tyr-Arg-OH
Sequence Shortening
KRREILSRRPSYR
InChIKey
QKXYCULATRFTIQ-KPXMCYQPSA-N
References
[1]. Wu J, et al. A microPLC-based approach for determining kinase-substrate specificity. Assay Drug Dev Technol. 2007 Aug;5(4):559-66. [2]. Colbran JL, et al. cAMP-dependent protein kinase, but not the cGMP-dependent enzyme, rapidly phosphorylates delta-CREB, and a synthetic delta-CREB peptide. Biochem Cell Biol. 1992 Oct-Nov;70(10-11):1277-82. [3]. Harum KH, et al. Cognitive impairment in Coffin-Lowry syndrome correlates with reduced RSK2 activation. Neurology. 2001 Jan 23;56(2):207-14.
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CREBtide, a synthetic 13 amino acid peptide, has been reported as a PKA substrate.