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Molecular structural formula
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Normal/Tumor
gut carcinoma(RNA)
gut carcinoma(RNA)
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HLA
DR13(用于人类白细胞抗原 II类)
DR13(用于人类白细胞抗原 II类)
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Peptide Sequence
LWWVNNQSLPVSP
LWWVNNQSLPVSP
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Position
177-189 and 355-367
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Lymphocyte Stimulation
peptide
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NCBI Gene SummaryNCBI
This gene encodes a cell surface glycoprotein that represents the founding member of the carcinoembryonic antigen (CEA) family of proteins. The encoded protein is used as a clinical biomarker for gastrointestinal cancers and may promote tumor development through its role as a cell adhesion molecule. Additionally, the encoded protein may regulate differentiation, apoptosis, and cell polarity. This gene is present in a CEA family gene cluster on chromosome 19. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]
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GeneCards Summary
CEACAM5 (CEA Cell Adhesion Molecule 5) is a Protein Coding gene. Diseases associated with CEACAM5 include Lung Non-Small Cell Carcinoma and Bile Duct Cancer. Among its related pathways are Metabolism of proteins and Response to elevated platelet cytosolic Ca2+. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and GPI anchor binding. An important paralog of this gene is CEACAM1.
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UniProtKB SwissProt Summary
Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, 10910050, 10864933). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050). ( CEAM5_HUMAN,P06731 )
(Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. (CEAM5_HUMAN,P06731)
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References
[1].Campi G, Crosti M, Consogno G, Facchinetti V, Conti-Fine BM, Longhi R, Casorati G, Dellabona P, Protti MP. CD4(+) T cells from healthy subjects and colon cancer patients recognize a carcinoembryonic antigen-specific immunodominant epitope. Cancer Res. 2003 Dec 1, 63(23):8481-6. (PMID: 14679013).
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