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Synthesis of unnatural amino acids and other blocks

Bremelanotide

Name
Bremelanotide
Molecular structural formula
CAS Number
189691-06-3
Formula
C50H68N14O10
MW
1025.18
Sequence Shortening
Ac-{Nle-Asp}-HdRWK
Sequence
Ac-Nle-Asp-His-D-Phe-Arg-Trp-Lys-OH
InChIKey
AOTMRIXFFOGWDT-UHFFFAOYSA-N
Purity
≥98%
References
[1]. Pfaus J, et al. Bremelanotide: an overview of preclinical CNS effects on female sexual function. J Sex Med. 2007 Nov;4 Suppl 4:269-79. [2]. Molinoff PB, et al. PT-141: a melanocortin agonist for the treatment of sexual dysfunction. Ann N Y Acad Sci. 2003 Jun;994:96-102.
Target
Melanocortin Receptor
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Product details
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Bremenotiide (PT-141) is a synthetic peptide that acts as a melanocortin receptor agonist that non-selectively activates multiple receptor subtypes, primarily binding to MC1R and MC4R. It modulates sexual desire and response by activating endogenous pathways in the brain.