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Bcl-2 Binding Peptide, cell permeable

Name
Bcl-2 Binding Peptide, cell permeable
Molecular structural formula
Purity
95%
CAS Number
220408-24-2
Formula
C153H240O42N44S1
MW
3399.88
Sequence
Decanoicacid-Lys-Asn-Leu-Trp-Ala-Ala-Gln-Arg-Tyr-Gly-Arg-Glu-Leu-Arg-Arg-Met-Ser-Asp-Glu-Phe-Glu-Gly-Ser-Phe-Lys-Gly-Leu-OH
Sequence Shortening
Decanoicacid-KNLWAAQRYGRELRRMSDEFEGSFKGL
References
[1].Wang, J-L., et al. 2000. Cancer Res.60, 1498. [2].Kelekar, A., et al. 1997. Mol. Cell. Biol.17, 7040.
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It is a peptide that binds to Bcl-2 with high affinity. It is derived from the BH3 domain (a death domain) of Bad, amino acid residues 140 to 165, and is cellular permeable due to the N-terminal modification by a decanoyl moiety.