Name
BING-4 -HLA A2(Peptide Sequence: CQWGRLWQL)
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Molecular structural formula
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Normal/Tumor
ubiquitous (low level)(RNA)
ubiquitous (low level)(RNA)
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Peptide Sequence
CQWGRLWQL
CQWGRLWQL
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Lymphocyte Stimulation
anti-CD3
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NCBI Gene SummaryNCBI
Enables RNA binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be located in nucleoplasm. Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. [provided by Alliance of Genome Resources, Apr 2022]
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GeneCards Summary
WDR46 (WD Repeat Domain 46) is a Protein Coding gene. Diseases associated with WDR46 include Asthma, Nasal Polyps, And Aspirin Intolerance. Among its related pathways are rRNA processing in the nucleus and cytosol and Processing of Capped Intron-Containing Pre-mRNA. Gene Ontology (GO) annotations related to this gene include RNA binding.
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UniProtKB SwissProt Summary
Scaffold component of the nucleolar structure. Required for localization of DDX21 and NCL to the granular compartment of the nucleolus (PubMed:23848194). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797). ( WDR46_HUMAN,O15213 )
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References
[1].Rosenberg SA, Tong-On P, Li Y, Riley JP, El-Gamil M, Parkhurst MR, Robbins PF. Identification of BING-4 cancer antigen translated from an alternative open reading frame of a gene in the extended MHC class II region using lymphocytes from a patient with a durable complete regression following immunotherapy. J Immunol. 2002 Mar 1, 168(5):2402-7. (PMID: 11859131).
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