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Synthesis of unnatural amino acids and other blocks

Axltide

Name
Axltide
Molecular structural formula
Purity
95%
CAS Number
143364-95-8
Formula
C63H107N19O20S2
MW
1514.77
Target
JAK
Sequence
Lys-Lys-Ser-Arg-Gly-Asp-Tyr-Met-Thr-Met-Gln-Ile-Gly
Sequence Shortening
KKSRGDYMTMQIG
InChIKey
YUBAIOSYCNQVBL-JAXABQKPSA-N
References
[1]. Wang H, et al. Cellular chromium enhances activation of insulin receptor kinase. Biochemistry. 2005 Jun 7;44(22):8167-75.
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Axltide is based on the mouse Insulin receptor substrate 1 (amino acid 979-989). Axltide is a substrate for Axl, DDR2, Mst1, and JAK2 kinases.