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Synthesis of unnatural amino acids and other blocks

Aviptadil

Name
Aviptadil
Molecular structural formula
Purity
≥98%
CAS Number
40077-57-4
Formula
C147H238N44O42S
MW
3325.8
Target
SARS-CoV
Sequence
His-Ser-Asp-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Leu-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH2
Sequence Shortening
HSDAVFTDNYTRLRKQMAVKKYLNSILN-NH2
Solubility in water
100 mg/mL
References
[1]. Intravenous Aviptadil for Critical COVID-19 With Respiratory Failure (COVID-AIV) [2]. Jian Hu, et al. Novel Targets of Drug Treatment for Pulmonary Hypertension. Am J Cardiovasc Drugs.
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Apildil acetate is an active peptide extracted from the mucosa of the small intestine. It is composed of 28 amino acid residues, which are arranged into a part glucagon and secretin, which can cause vasodilation and lower blood pressure. Starting from the hepatic artery, it has a strong ability to act on the splanchnic blood vessels, but has no effect on the femoral artery at all. It has a strong promoting effect on the secretion of intestinal fluid, but its promoting effect on the secretion of pancreas is very weak, and it can inhibit the secretion of gastric juice and the contraction of smooth muscle of the digestive tract.