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Synthesis of unnatural amino acids and other blocks

Antide

Name
Antide
Molecular structural formula
CAS Number
112568-12-4
Formula
C82H108ClN17O14
MW
1591.29
Sequence Shortening
Ac-DNal(2)-DPhe(pCl)-DPal(3)-S-Lys(Nic)-DLys(Nic)-L-Lys(iPr)-P-DAla-NH2
Sequence
Ac-DNal(2)-DPhe(4Cl)-DPal(3)-Ser-Lys(Nic)-DLys(Nic)-Leu-Lys(iPr)-Pro-DAla-NH2
InChIKey
QRYFGTULTGLGHU-NBERXCRTSA-N
Solubility in water
10 mg/mL
Purity
≥98%
References
[1]. U F Habenicht, et al. Effect of the new potent LHRH antagonist antide. J Steroid Biochem Mol Biol. 1990 Dec 20;37(6):937-42.
Target
GnRH Receptor
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Product details
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Antide is a synthetic nonapeptide compound with dual functions. On the one hand, the compound can simulate the mechanism of action of growth hormone-releasing hormone (GHRH), thereby promoting the secretion of growth hormone (GH), and is currently widely studied for anti-aging, muscle reconstruction, and bone strengthening. On the other hand, Antide, as an LHRH antagonist, can effectively reduce the secretion of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by competitively binding to GnRH receptors, and therefore has been used in the treatment of male-related diseases.