Endogenous peptide. Potent amylin, calcitonin (EC50 = 0.67 nM), CGRP and adrenomedullin receptor agonist. Potently inhibits insulin-stimulated glucose uptake in skeletal muscle cells (IC50 = 12 pM). Implicated in type II diabetes. Active in vivo. Rat (ab142399) and feline (ab142397) amylin also available.