Name
Alpha-foetoprotein (AFP) -HLA A2(Peptide Sequence: GVALQTMKQ)
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Molecular structural formula
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Normal/Tumor
liver(RNA)
liver(RNA)
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Peptide Sequence
GVALQTMKQ
GVALQTMKQ
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Lymphocyte Stimulation
adenovirus-dendritic cells
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NCBI Gene SummaryNCBI
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]
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GeneCards Summary
AFP (Alpha Fetoprotein) is a Protein Coding gene. Diseases associated with AFP include Alpha-Fetoprotein Deficiency and Alpha-Fetoprotein, Hereditary Persistence Of.
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UniProtKB SwissProt Summary
Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties. ( FETA_HUMAN,P02771 )
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References
[1].Butterfield LH, Koh A, Meng W, Vollmer CM, Ribas A, Dissette V, Lee E, Glaspy JA, McBride WH, Economou JS. Generation of human T-cell responses to an HLA-A2.1-restricted peptide epitope derived from alpha-fetoprotein. Cancer Res. 1999 Jul 1, 59(13):3134-42. (PMID: 10397256).
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