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Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide

Name
Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide
Molecular structural formula
Purity
≥95%
CAS Number
819048-44-7
Formula
C51H72N18O11S2
MW
1177.36
Target
Melanocortin Receptor
Sequence
Ac-D-Arg-Cys-Glu-His-D-Phe-Arg-Trp-Cys-NH2(Disulfide bridge: Cys2-Cys8)
Sequence Shortening
Ac-{D-Arg}-CEH-{D-Phe}-RWC-NH2 (Disulfide bridge: Cys2-Cys8)
InChIKey
ZUGUOZWTPYJYJW-ZSTGMXRXSA-N
References
[1]. Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R)-Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64(9):5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66(10):7063-7065.
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Product details
Data download

Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide is a cyclic octapeptide with MC4R agonism. Acetyl-(D-Arg10,Cys11,D-Phe14,Cys17)-β-MSH (10-17) amide significantly increases heart rate and blood pressure.