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Ac-YVAD-pNA

Name
Ac-YVAD-pNA
Molecular structural formula
Purity
≥95%
CAS Number
149231-66-3
Formula
C29H36N6O10
MW
628.6
Target
Caspase
Sequence
Ac-Tyr-Val-Ala-Asp-pNA
Sequence Shortening
Ac-YVAD-pNA
InChIKey
YDPNOCSPPGFBPX-XNHCRPTKSA-N
Solubility in DMSO
≥ 250 mg/mL
References
[1]. Pereira NA, et al. Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity. Biochem Biophys Res Commun. 2008 Dec 19;377(3):873-7. [2]. Xin W, Wang Q, et al. A new mechanism of inhibition of IL-1β secretion by celastrol through the NLRP3 inflammasome pathway. Eur J Pharmacol. 2017 Nov 5;814:240-247.
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Ac-YVAD-pNA is a specific Caspase-1 substrate. Ac-YVAD-pNA can be used to detect Caspase-1 activity. Caspase-1 is a key mediator of inflammatory processes.