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Synthesis of unnatural amino acids and other blocks

Abarelix

Name
Abarelix
Molecular structural formula
Purity
≥98%
CAS Number
183552-38-7
Formula
C72H95ClN14O14
MW
1416.1
Sequence
Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-Ser-N(Me)Tyr-D-Asn-Leu-Lys(iPr)-Pro-D-Ala-NH2
Sequence Shortening
Ac-D-2Nal-D-Phe(4-Cl)-D-3Pal-S-N(Me)Tyr-nLK(iPr)-Pa-NH2
InChIKey
AIWRTTMUVOZGPW-HSPKUQOVSA-N
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Abarelix is a synthetic decapeptide compound that acts as a synthetic antagonist of gonadotropin-releasing hormone (GnRH). By directly blocking the GnRH receptors in the anterior pituitary, Abarelix can inhibit the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby effectively reducing serum testosterone levels to castrate levels.