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Synthesis of unnatural amino acids and other blocks

3,6,9,12,15,18-hexaoxaicosanedioic acid

Name
3,6,9,12,15,18-hexaoxaicosanedioic acid
Molecular structural formula
Purity
≥95%
CAS Number
77855-76-6
Formula
C14H26O10
MW
354.35
Target
PROTAC Linkers
InChIKey
DCQRSABUSOYSIY-UHFFFAOYSA-N
References
[1]. Maniaci C, et al. Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation. Nat Commun. 2017 Oct 10;8(1):830.
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PEG6-(CH2CO2H)2 is a symmetric PEG PROTAC linker, for the synthesis of Homo-PROTACs which is bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.