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(p-Iodo-Phe7)-ACTH (4-10)

Name
(p-Iodo-Phe7)-ACTH (4-10)
Molecular structural formula
Purity
≥95%
CAS Number
159600-82-5
Formula
C44H58IN13O10S
MW
1087.98
Target
Melanocortin Receptor
Sequence
Met-Glu-His-P-Iodo-Phe-Arg-Trp-Gly
Sequence Shortening
MEH-{p-Iodo-Phe}-RWG
InChIKey
JEHNDLZVGYWOAY-LXOXETEGSA-N
Solubility in water
<1mg/mL
References
[1]. Adan RA, et al. Identification of antagonists for melanocortin MC3, MC4 and MC5 receptors. Eur J Pharmacol. 1994 Nov 15;269(3):331-7. [2]. Schiöth HB, et al. Selectivity of [Phe-I7], [Ala6], and [D-Ala4,Gln5,Tyr6] substituted ACTH(4-10) analogues for the melanocortin receptors. Peptides. 1997;18(5):761-3.
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(p-Iodo-Phe7)-ACTH (4-10) is a adrenocorticotrophic hormone (ACTH) derivative, which is produced and secreted by the anterior pituitary gland. (p-Iodo-Phe7)-ACTH (4-10) serves as a melanocortin (MC) receptor antagonist and inhibits α-melanocyte-stimulating hormone (α-MSH)-induced excessive grooming behavior in rats.