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(D-Phe12,Nle21·38,α-Me-Leu37)-CRF (12-41) (human, rat)

Name
(D-Phe12,Nle21·38,α-Me-Leu37)-CRF (12-41) (human, rat)
Molecular structural formula
Purity
≥95%
CAS Number
150646-45-0
Formula
C159H267N49O43
MW
3553.12
Target
CRFR
Sequence
D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-α-Me-Leu-Nle-Glu-Ile-Ile-NH2|H-D-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Nle-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-α-Me-Leu-Nle-Glu-Ile
Sequence Shortening
{D-Phe}-HLLREVLE-{Nle}-ARAEQLAQQAHSNRK-{Leu(α-Me)}-{Nle}-EII-NH2
InChIKey
ZRVJFWQRMVCTQT-YWHUVQRVSA-N
References
[1]. Feng YJ, et al. An inhibitory effects of interleukin-1a on basal gonadotropin release in the ovariectomized rhesus monkey: reversal by a corticotropin-releasing factor antagonist. Endocrinology. 1991 Apr;128(4):2077-82.
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Product details
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(D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) is a CRF antagonist. (D-Phe12,Nle21,38,α-Me-Leu37)-CRF (12-41) (human, rat) prevents the IL-1a induced Luteinizing hormone (LH) inhibition.