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Satralizumab Linker
Name
Satralizumab Linker
Molecular structural formula
Purity
≥95%
CAS Number
1491917-83-9
Formula
C76H104N12O24S
MW
1601.8
Target
Antibody-Drug Conjugates (ADCs) TROP2
InChIKey
ULRUOUDIQPERIJ-PQURJYPBSA-N
Solubility in water
25 mg/mL
References
[1]. Cardillo TM, et al. Sacituzumab Govitecan (IMMU-132), an Anti-Trop-2/SN-38 Antibody-Drug Conjugate: Characterization and Efficacy in Pancreatic, Gastric, and Other Cancers. Bioconjug Chem. 2015 May 20;26(5):919-31. [2]. Goldenberg DM, Cardillo TM, Govindan SV, Rossi EA, Sharkey RM. Trop-2 is a novel target for solid cancer therapy with sacituzumab govitecan (IMMU-132), an antibody-drug conjugate (ADC) [published correction appears in Oncotarget. 2020 Mar 10;11(10):942]. Oncotarget. 2015;6(26):22496-22512.
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Sacituzumab govitecan  is an antibody-drug conjugate (ADC) targeting Trop-2 for delivery of SN-38. Sacituzumab govitecan shows anticancer activity.