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Tetrazine-PEG4-SS-NHS
Name
Tetrazine-PEG4-SS-NHS
Molecular structural formula
Purity
≥95%
CAS Number
N/A
Formula
C30H41N7O10S2
MW
723.82
Target
ADC Linker
InChIKey
TVJRYTCIZCBJRI-UHFFFAOYSA-N
References
[1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.
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Tetrazine-PEG4-SS-NHS is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetrazine-PEG4-SS-NHS is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.