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Molecular structural formula
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Normal/Tumor
head and neck squamous cell carcinoma
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Peptide Sequence
FPSDSWCYF(其中"SWCYF"为独特抗原突变所导致的修饰残基)
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Lymphocyte Stimulation
autologous tumor cells
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NCBI Gene SummaryNCBI
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit.
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GeneCards Summary
CASP8 (Caspase 8) is a Protein Coding gene. Diseases associated with CASP8 include Caspase 8 Deficiency and Hepatocellular Carcinoma. Among its related pathways are MyD88 dependent cascade initiated on endosome and TNFR1 Pathway. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and protein-containing complex binding. An important paralog of this gene is CASP10.
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UniProtKB SwissProt Summary
Thiol protease that plays a key role in programmed cell death by acting as a molecular switch for apoptosis, necroptosis and pyroptosis, and is required to prevent tissue damage during embryonic development and adulthood . Initiator protease that induces extrinsic apoptosis by mediating cleavage and activation of effector caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death . Cleaves and activates effector caspases CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10 . Binding to the adapter molecule FADD recruits it to either receptor TNFRSF6/FAS mediated or TNFRSF1A . The resulting aggregate called death-inducing signaling complex (DISC) performs CASP8 proteolytic activation . The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases . Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC.
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References
[1].Mandruzzato S, Brasseur F, Andry G, Boon T, van der Bruggen P. A CASP-8 mutation recognized by cytolytic T lymphocytes on a human head and neck carcinoma. J Exp Med. 1997 Aug 29, 186(5):785-93. (PMID: 9271594).
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