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Home / Peptide products / H (67 species) / Helospectin / Helospectin II
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Helospectin II
Name
Helospectin II
Molecular structural formula
Purity
≥95%
CAS Number
93585-83-2
Formula
C180H288N46O57
MW
4008.58
Target
others
Sequence
His-Ser-Asp-Ala-Thr-Phe-Thr-Ala-Glu-Tyr-Ser-Lys-Leu-Leu-Ala-Lys-Leu-Ala-Leu-Gln-Lys-Tyr-Leu-Glu-Ser-Ile-Leu-Gly-Ser-Ser-Thr-Ser-Pro-Arg-Pro-Pro-Ser
Sequence Shortening
HSDATFTAEYSKLLAKLALQKYLESILGSSTSPRPPS
InChIKey
LKDLKXMXYPSIRO-ZXFPMOGVSA-N
Solubility in water
50 mg/mL
References
[1]. Tsueshita T, et al. Helospectin I and II evoke vasodilation in the intact peripheral microcirculation. Peptides. 2004 Jan;25(1):65-9. [2]. Grundemar L, et al. Vascular effects of helodermin, helospectin I and helospectin II: a comparison with vasoactive intestinal peptide (VIP). Br J Pharmacol. 1990 Mar;99(3):526-8.
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Helospectin II is a neuropeptide of the vasoactive intestinal peptide (VIP) family. Helospectin II has vasodilatory and antihypertensive activities, and decreases blood pressure. Helospectin II is originally isolated from the salivary gland venom of the lizard Heloderma suspectum.