Home / Peptide products / H (67 species) / HIV / IV9 (476 - 484), HIV - 1 RT Epitope
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IV9 (476 - 484), HIV - 1 RT Epitope
Name
IV9 (476 - 484), HIV - 1 RT Epitope
Molecular structural formula
Purity
≥95%
Formula
C46H78N12O12
MW
991.21
Target
HIV1
Sequence
Ile-Leu-Lys-Glu-Pro-Val-His-Gly-Val
Sequence Shortening
ILKEPVHGV
References
[1].Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses J Immunol . 2003 Nov 15 ; 171(10) 5372 . [2].IFN-γ Exposes a Cryptic Cytotoxic T Lymphocyte Epitope in HIV-1 Reverse Transcriptase J Immunol . 1999 Jun 15 ; 162(12) 7075. [3].Lack of strong immune selection pressure by the immunodominant, HLA-A 0201-restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus-1 infection.J Clin Invest . 1998 Jun 01 ; 101(11) 2559.
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This is a reverse transcriptase (RT) epitope (Pol residues 476-484). Within HIV-1 RT the peptide appears to be the dominant HLA A*0201-restricted epitope. Was used to investigate possible mechanisms behind HIV-1 escape from CTL. IV9 is the actual epitope processed and presented in HIV-1-infected cell lines.